(c) Calcipotriol ointment treatment resulted in complete clinical remission after 3 months of treatment in a case of AA.Īfter obtaining written informed consent from the patient's parents, we prescribed calcipotriol solution (Daivonex, 50µg/ml) to be applied once daily for 3 months. (b) The same patient after 1 month of treatment with topical calcipotriol. (a) Central view of a 7-year-old patient with alopecia areata (AA) before treatment. In this case, we found reduced VDR expression in AA, recovery from which was observed after topical application of calcipotriol, a strong vitamin D analog. However, the expression pattern of VDR in AA of the human scalp has not yet been reported. ![]() A therapeutic effect of vitamin D analog on hair loss in neonatal rats was recently reported 3. The duration of complete response to therapy may be related to a patient's inherent immune response rather to the treatment used. Although several treatment modalities appear to be effective, some severe cases do not achieve complete response and may relapse after therapy. A role of the immune system in the pathogenesis of this disease is supported by strong evidence. In addition, patients with hereditary 1,25-dihydroxyvitamin D3-resistant rickets type II and VDR knockout mice exhibit a phenotype that includes alopecia 4, 5.Īlopecia areata (AA) is an inflammatory hair loss of unknown etiology. Expression of VDR in keratinocytes is necessary for maintenance of the normal hair cycle 3. A lack of VDR is associated with reduced epidermal differentiation and hair follicle growth 3. ![]() It has been demonstrated that VDR is strongly expressed in the key structures of human and murine hair follicles 1. VDR is a member of the nuclear hormone receptor superfamily that acts as a ligand-inducible transcription factor regulating vitamin D-responsive genes 1. The active form of vitamin D, 1,25-dihydroxyvitamin D3, mediates its action by binding to specific vitamin D receptors (VDR) located in the nuclei of target cells 2. Vitamin D is a hormone that plays an important role in calcium homeostasis, immune regulation, and cell growth and differentiation 1. ![]() Hair follicles are highly sensitive to hormones 1.
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